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The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint

27 Nov 2017

Abstract excerpt

Engagement of programmed death-ligand 1 (PD-L1) with its receptor programmed death 1 (PD-1) on T cells has been speculated to play a major role in suppressing the immune system, which helps tumor cells evade anti-tumor immunity. With the development of whole genome sequencing technologies, microRNAs have gained more attention as an important new layer of molecular regulation. Recent studies have revealed that...

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PMID: 29186904
DOI: 10.3390/ijms18122540

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