Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pyrimethamine inhibits cell growth by inducing cell senescence and boosting CD8+ T-cell mediated cytotoxicity in colorectal cancer

9 Mar 2022

Abstract excerpt

Abstract Background The emergence of nonresponse or resistance to traditional chemotherapeutic agents is one of the main challenges of colorectal cancer (CRC) therapies. Thus, novel therapeutic drugs that can improve the clinical outcomes of CRC patients are urgently needed. The purpose of this study was to investigate the effects and mechanisms of pyrimethamine in CRC. Methods and results In this study, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35262820
DOI: 10.1007/s11033-022-07262-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pyrimethamine inhibits cell growth by inducing cell senescence and boosting CD8+ T-cell mediated cytotoxicity in colorectal cancerPMID 35262820Read ↗

Qizhu anticancer prescription enhances immunosurveillance of liver cancer cells by regulating p21-dependent secretory phenotypes.Semantic proximity Read ↗

Antitumor Effects of N-Butylidenephthalide Encapsulated in Lipopolyplexs in Colorectal Cancer CellsSemantic proximity Read ↗

A novel cell senescence-related IncRNA survival model associated with the tumor immune environment in colorectal cancerSemantic proximity Read ↗

NSC666715 and Its Analogs Inhibit Strand-Displacement Activity of DNA Polymerase β and Potentiate Temozolomide-Induced DNA Damage, Senescence and Apoptosis in Colorectal Cancer CellsSemantic proximity Read ↗

Applications and mechanisms of the cyclin-dependent kinase 4/6 inhibitor, PD-0332991, in solid tumorsSemantic proximity Read ↗

Pro-tumorigenic role of type 2 diabetes-induced cellular senescence in colorectal cancerSemantic proximity Read ↗

Nitidine chloride inhibits proliferation and induces apoptosis in colorectal cancer cells by activating the p53 signaling pathwaySemantic proximity Read ↗

Berberine inhibits tumour growth in vivo and in vitro through suppressing the lincROR-Wnt/β-catenin regulatory axis in colorectal cancerSemantic proximity Read ↗

Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colonSemantic proximity Read ↗

Furazolidone induced oxidative DNA damage via up-regulating ROS that caused cell cycle arrest in human hepatoma G2 cells.Semantic proximity Read ↗

Melatonin and Cancer HallmarksSemantic proximity Read ↗

G9a/GLP inhibitor UNC0642 induces growth arrest in colorectal cancer via induction of ROS generation, coordinated overexpression of GADD genes, and the JNK/p38 MAPK pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.