Novel insight into the gene etiology of ulcerative colitis gained from transcriptome association study and single-cell sequence analysis.

Abstract excerpt

Ulcerative colitis (UC) is a prevalent chronic gastrointestinal disease. Gene plays an important role in UC pathogenesis. Therefore, we aim to identify UC susceptibility genes and specific cell types expressing these genes. We conducted a cross-tissue transcriptome-wide association study by integrating UC GWAS with 49 tissues gene expression matrix from the Genotype-Tissue Expression project. Subsequently, we...

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