Article
An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
PloS one - 31 Jan 2011
Juyal Garima, Prasad Pushplata, Senapati Sabyasachi, Midha Vandana, Sood Ajit, Amre Devendra, Juyal Ramesh C, BK Thelma
Abstract excerpt
Genome-Wide Association studies (GWAS) of both Crohn's Disease (CD) and Ulcerative Colitis (UC) have unearthed over 40 risk conferring variants. Recently, a meta-analysis on UC revealed several loci, most of which were either previously associated with UC or CD susceptibility in populations of European origin. In this study, we attempted to replicate these findings in an ethnically distinct north Indian UC...
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