Article
Genome-wide association scan in north Indians reveals three novel HLA-independent risk loci for ulcerative colitis.
Gut - 1 Apr 2015
Juyal Garima, Negi Sapna, Sood Ajit, Gupta Aditi, Prasad Pushplata, Senapati Sabyasachi, Zaneveld Jacques, Singh Shalini, Midha Vandana, van Sommeren Suzanne, Weersma Rinse K, Ott Jurg, Jain Sanjay, Juyal Ramesh C, Thelma B K
Abstract excerpt
OBJECTIVE: Over 100 ulcerative colitis (UC) loci have been identified by genome-wide association studies (GWASs) primarily in Caucasians (CEUs). Many of them have weak effects on disease susceptibility, and the bulk of the heritability cannot be ascribed to these loci. Very little is known about the genetic background of UC in non-CEU groups. Here we report the first GWAS on UC in a genetically distinct north...
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