Article

Hyperactivity of indirect pathway-projecting spiny projection neurons drives compulsive behavior

2022-02-18

Abstract excerpt

Compulsive behaviors are a hallmark symptom of obsessive compulsive disorder (OCD). Striatal hyperactivity has been linked to compulsive behavior generation in correlative studies in humans and causal studies in rodents. However, the contribution of the two distinct striatal output populations to the generation and treatment of compulsive behavior is unknown. These populations of direct and indirect pathway-projec...

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Literature Corpus work: 1a7a0f60-e928-5200-ba4e-2ffd5e2c0b09
DOI: 10.1101/2022.02.17.480966

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