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Separate BNST Microcircuits Targeted by Direct Versus Amygdala-Relayed Prefrontal Inputs Mediate Dissociable Phenotypes After Isolation.

Cells - 8 Jan 2026

Yuan Hongxia, Zhong Yongmei, Zhang Xuehan

Abstract excerpt

Anxiety, depression, and social impairment exhibit high clinical comorbidity, yet their underlying shared neural circuitry remains poorly defined. Using a mouse model of chronic social isolation combined with circuit tracing and chemogenetic tools, we identified a key role for the basolateral amygdala (BLA) in relaying prefrontal cortex (PFC) signals to the bed nucleus of the stria terminalis (BNST) to drive...

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Identifiers

PMID: 41597191
DOI: 10.3390/cells15020116
PMCID: PMC12839825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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