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Article

Differential Effects of Deep Brain Stimulation of the Internal Capsule and the Striatum on Excessive Grooming in Sapap3 Mutant Mice.

Biological psychiatry - 15 Dec 2018

Pinhal Cindy M, van den Boom Bastijn J G, Santana-Kragelund Fabiana, Fellinger Lizz, Bech Pol, Hamelink Ralph, Feng Guoping, Willuhn Ingo, Feenstra Matthijs G P, Denys Damiaan

Abstract excerpt

BACKGROUND: Deep brain stimulation (DBS) is an effective treatment for patients with obsessive-compulsive disorder (OCD) that do not respond to conventional therapies. Although the precise mechanism of action of DBS remains unknown, modulation of activity in corticofugal fibers originating in the prefrontal cortex is thought to underlie its beneficial effects in OCD. METHODS: To gain more mechanistic insight into...

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PMID: 29954580
DOI: 10.1016/j.biopsych.2018.05.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential Effects of Deep Brain Stimulation of the Internal Capsule and the Striatum on Excessive Grooming in Sapap3 Mutant Mice.PMID 29954580Read ↗

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