Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice.

Nature - 23 Aug 2007

Welch Jeffrey M, Lu Jing, Rodriguiz Ramona M, Trotta Nicholas C, Peca Joao, Ding Jin-Dong, Feliciano Catia, Chen Meng, Adams J Paige, Luo Jianhong, Dudek Serena M, Weinberg Richard J, Calakos Nicole, Wetsel William C, Feng Guoping

Abstract excerpt

Obsessive-compulsive disorder (OCD) is an anxiety-spectrum disorder characterized by persistent intrusive thoughts (obsessions) and repetitive actions (compulsions). Dysfunction of cortico-striato-thalamo-cortical circuitry is implicated in OCD, although the underlying pathogenic mechanisms are unknown. SAP90/PSD95-associated protein 3 (SAPAP3; also known as DLGAP3) is a postsynaptic scaffolding protein at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Face
Share to Grooming

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neostriatum

Share to Obsessive-Compulsive Disorder

Share to Receptors, N-Methyl-D-Aspartate

Share to Self-Injurious Behavior

Share to Synapses

Share to Synaptic Transmission

Source

Open in PubMed Open full text

Identifiers

PMID: 17713528
DOI: 10.1038/nature06104
PMCID: PMC2442572

Genes

DLGAP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice.PMID 17713528Read ↗

Sapap3 and pathological grooming in humans: Results from the OCD collaborative genetics study.Semantic proximity Read ↗

Non-synaptic alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behaviorSemantic proximity Read ↗

Premorbid Characteristics of the SAPAP3-Mouse Model of Obsessive-Compulsive Disorder: Behavior, Neuroplasticity, and Psilocybin TreatmentSemantic proximity Read ↗

Differential Effects of Deep Brain Stimulation of the Internal Capsule and the Striatum on Excessive Grooming in Sapap3 Mutant Mice.Semantic proximity Read ↗

Hyperactivity of indirect pathway-projecting spiny projection neurons drives compulsive behaviorSemantic proximity Read ↗

Investigating SAPAP3 variants in the etiology of obsessive-compulsive disorder and trichotillomania in the South African white population.Semantic proximity Read ↗

Association of <i>SAPAP3</i> allelic variants with symptom dimensions and pharmacological treatment response in obsessive-compulsive disorderSemantic proximity Read ↗

Behavioral flexibility in an OCD mouse model: Impaired Pavlovian reversal learning in SAPAP3 mutantsSemantic proximity Read ↗

Striking Long Term Beneficial Effects of Single Dose Psilocybin and Psychedelic Mushroom Extract in the SAPAP3 Rodent Model of OCD-Like Excessive Self-GroomingSemantic proximity Read ↗

Family-based genetic association study of DLGAP3 in Tourette Syndrome.Semantic proximity Read ↗

Not only compulsivity: The SAPAP3-KO mouse reconsidered as a comorbid model expressing a spectrum of pathological repetitive behaviorsSemantic proximity Read ↗

Association of SAPAP3 allelic variants with symptom dimensions and pharmacological treatment response in obsessive-compulsive disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.