Article

Behavioral flexibility in an OCD mouse model: Impaired Pavlovian reversal learning in SAPAP3 mutants

2018-10-04

Abstract excerpt

<h4>ABSTRACT</h4> Obsessive-compulsive disorder (OCD) is characterized by obsessive thinking, compulsive behavior, and anxiety, and is often accompanied by cognitive deficits. The neuropathology of OCD involves dysregulation of cortical-striatal circuits. Similar to OCD patients, SAPAP3 knockout mice 3 (SAPAP3 −/− ) exhibit compulsive behavior (grooming), anxiety, and dysregulated cortical-striatal function. How...

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Literature Corpus work: 0859c1af-a0ed-5f99-bdf6-07c5d40a6f3a
DOI: 10.1101/435172

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