Article

Reduced lysosomal activity and increased amyloid beta accumulation in silica-coated magnetic nanoparticles-treated microglia

2022-08-02

Abstract excerpt

<h4>Background: </h4> Nanoparticles have been used in neurological research in recent years because of their blood-brain barrier penetration activity. However, their potential neuronanotoxicity remains a concern. In particular, microglia, which are resident phagocytic cells, are mainly exposed to nanoparticles in the brain. Methods We investigated the changes in lysosomal function in silica-coated magnetic nanopa...

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Literature Corpus work: 1a664c20-2391-540b-8efb-40be9c4efef8
DOI: 10.21203/rs.3.rs-1904093/v1

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