Article

Size and surface modification of silica nanoparticles affect the severity of lung toxicity by modulating endosomal ROS generation in macrophages

2020-10-14

Abstract excerpt

<title>Abstract</title> <p>BackgroundAs the application of silica nanomaterials continues to expand, increasing chances of its exposure to the human body and potential harm are anticipated. Although the toxicity of silica nanomaterials is assumed to be affected by their physio-chemical properties, including size and surface functionalization, its molecular mechanism remains unclear. ResultsWe employed a murine in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5fb30d3e-8b22-5174-8541-97f1a91678ce
DOI: 10.21203/rs.3.rs-90322/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Size and surface modification of silica nanoparticles affect the severity of lung toxicity by modulating endosomal ROS generation in macrophagesDOI 10.21203/rs.3.rs-90322/v1Read

Time-course Analysis of Pulmonary Inflammation Induced by Intratracheal Instillation of Fine Crystalline Silica ParticlesSemantic proximity Read

Cell Culture and Animal Models of Nanoparticle Toxicity on the Airway BarrierSemantic proximity Read

The Nanomaterial-Induced Bystander Effects Reprogrammed Macrophage Immune FunctionSemantic proximity Read

Hazard and risk assessment strategies for nanoparticle exposures: how far have we come in the past 10 years?Semantic proximity Read

Dysregulation of macrophage activation profiles by engineered nanoparticles.Semantic proximity Read

Modulatory effects of CeO2 nanoparticles on bleomycin-induced active pulmonary disease processes in animal and human airway epithelium modelsSemantic proximity Read

Size-Dependent Uptake of Particles by Pulmonary Antigen-Presenting Cell Populations and Trafficking to Regional Lymph NodesSemantic proximity Read

Particle Phagocytosis Amplifies Secretion of Small Extracellular Vesicles in MacrophagesSemantic proximity Read

Ultrafine amorphous silica induces chronic lung epithelial cell stress and pro-fibrotic reprogramming in a particle size‑ and exposure duration‑dependent mannerSemantic proximity Read

Comparative RNA‐Seq transcriptome analysis on silica induced pulmonary inflammation and fibrosis in mice silicosis modelSemantic proximity Read

Inorganic material based macrophage regulation for cancer therapy: basic concepts and recent advances.Semantic proximity Read

Mechanistic Study of Silica Nanoparticles on the Size-dependent Retinal Toxicity in Vitro and in VivoSemantic proximity Read