Article
High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability.
BMC cancer - 23 Feb 2021
Matson Daniel R, Denu Ryan A, Zasadil Lauren M, Burkard Mark E, Weaver Beth A, Flynn Christopher, Stukenberg P Todd
Abstract excerpt
BACKGROUND: Targeting Protein for Xenopus Kinesin Like Protein 2 (TPX2) is a microtubule associated protein that functions in mitotic spindle assembly. TPX2 also localizes to the nucleus where it functions in DNA damage repair during S-phase. We and others have previously shown that TPX2 RNA levels are strongly associated with chromosomal instability (CIN) in breast and other cancers, and TPX2 RNA levels have...
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