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Article

FoxM1 Is Up-Regulated by Obesity and Stimulates β-Cell Proliferation

21 Jul 2010

Abstract excerpt

beta-Cell mass expansion is one mechanism by which obese animals compensate for insulin resistance and prevent diabetes. FoxM1 is a transcription factor that can regulate the expression of multiple cell cycle genes and is necessary for the maintenance of adult beta-cell mass, beta-cell proliferation, and glucose homeostasis. We hypothesized that FoxM1 is up-regulated by nondiabetic obesity and initiates a...

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Identifiers

PMID: 20660304
DOI: 10.1210/me.2010-0082

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