Multipotent hematopoietic progenitors divide asymmetrically to create progenitors of the lymphomyeloid and erythromyeloid lineages.

doi:10.1016/j.stemcr.2014.09.016

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Article

Multipotent hematopoietic progenitors divide asymmetrically to create progenitors of the lymphomyeloid and erythromyeloid lineages.

Stem cell reports - 9 Dec 2014

Görgens André, Ludwig Anna-Kristin, Möllmann Michael, Krawczyk Adalbert, Dürig Jan, Hanenberg Helmut, Horn Peter A, Giebel Bernd

Abstract excerpt

Hematopoietic stem and progenitor cells (HSPCs) can self-renew and create committed progenitors, a process supposed to involve asymmetric cell divisions (ACDs). Previously, we had linked the kinetics of CD133 expression with ACDs but failed to detect asymmetric segregation of classical CD133 epitopes on fixed, mitotic HSPCs. Now, by using a novel anti-CD133 antibody (HC7), we confirmed the occurrence of...

Topics

Animals
Antigens, Surface
Asymmetric Cell Division
Cell Adhesion
Cell Differentiation
Cell Lineage
Cell Movement
Cells, Cultured
Colony-Forming Units Assay
Erythroid Precursor Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hematopoiesis

Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cells

Heterografts

Humans

Immunophenotyping

Lymphoid Progenitor Cells

Mice

Source

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Identifiers

PMID: 25448068
DOI: 10.1016/j.stemcr.2014.09.016
PMCID: PMC4263999

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