An Intact Centrosome Is Required for the Maintenance of Polarization during Directional Cell Migration

Abstract excerpt

BACKGROUND: Establishing and maintaining polarization is critical during cell migration. It is known that the centrosome contains numerous proteins whose roles of organizing the microtubule network range include nucleation, stabilization and severing. It is not known whether the centrosome is necessary to maintain polarization. Due to its role as the microtubule organizing center, we hypothesize that the...

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