Article

The BAF complex works with FOS to regulate human neuronal activity-dependent ASD-associated gene programs

2026-08-27

Abstract excerpt

The BAF chromatin remodeling complex is critical to normal brain development, and rare variants within genes encoding BAF subunits are a common genetic cause of neurodevelopmental disorders, including autism spectrum disorder (ASD). Yet the factors that direct BAF binding across the neuronal genome, the human neuronal gene programs that are regulated by BAF, and the mechanisms whereby BAF subunit perturbation lead...

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Literature Corpus work: 1a176ca9-3f31-5030-8209-eb4d086e5d37
DOI: 10.64898/2026.08.25.747063

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