Article

Autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes

2022-10-18

Abstract excerpt

Many autism spectrum disorder (ASD)-associated genes act as transcriptional regulators (TRs). ChIP-seq was used to identify the regulatory targets of ARID1B, BCL11A, FOXP1, TBR1, and TCF7L2, ASD-associated TRs in the developing human and mouse cortex. These TRs shared substantial overlap in the binding sites, especially within open chromatin. The overlap within a promoter region, 1-2,000bp upstream of transcriptio...

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Literature Corpus work: 40c3d3ab-0680-5c5a-9529-c8e53afa6cee
DOI: 10.1101/2022.10.17.512583

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