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TRBP modulates RLR signaling by inhibiting PKR-mediated antiviral stress granule formation

1 Jul 2025

Abstract excerpt

Stress granules (SGs) are dense aggregates of RNA and proteins that form in response to various cellular stresses. Virus-induced SGs, known as antiviral SGs (avSGs), play a crucial role in regulating retinoic acid-inducible gene I-like receptors (RLRs)-mediated antiviral innate immunity. However, the regulation of avSG formation remains not fully understood. In this study, we demonstrate that TAR-RNA binding...

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PMID: 40593223
DOI: 10.1038/s41598-025-07121-3

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