Article

Interleukin-8/CXCR2 signaling regulates therapy-induced plasticity and enhances tumorigenicity in glioblastoma

2018-11-09

Abstract excerpt

<h4>SUMMARY</h4> Glioblastoma (GBM) remains one of the least treatable types of cancer. Recent work highlights two key factors contributing to this resistant phenotype—cellular plasticity, the ability of GBM cells to adopt many phenotypes, and the microenvironment. Here, we provide evidence that Interleukin-8 (IL-8) plays a vital role in promoting cellular plasticity and cancer initiating cells (CICs) niche durin...

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Literature Corpus work: 19de7cf8-9f21-5c9e-884c-b8f9d4530c96
DOI: 10.1101/454553

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