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Article

Impact of epigenetic reprogramming on antitumor immune responses in glioma.

The Journal of clinical investigation - 17 Jan 2023

McClellan Brandon L, Haase Santiago, Nunez Felipe J, Alghamri Mahmoud S, Dabaja Ali A, Lowenstein Pedro R, Castro Maria G

Abstract excerpt

Epigenetic remodeling is a molecular hallmark of gliomas, and it has been identified as a key mediator of glioma progression. Epigenetic dysregulation contributes to gliomagenesis, tumor progression, and responses to immunotherapies, as well as determining clinical features. This epigenetic remodeling includes changes in histone modifications, chromatin structure, and DNA methylation, all of which are driven by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36647827
DOI: 10.1172/JCI163450
PMCID: PMC9843056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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