Article

Differential DNA Methylation Patterns in Primary and Recurrent Glioblastoma : A Protumorigenic Role for the TEM8 Gene

2022-03-03

Abstract excerpt

<h4>Introduction: </h4> Glioblastomas are infiltrative malignant brain tumors which mostly recur within a year’s time, following surgical resection and chemo-radiation therapy. Studies on glioblastoma cells following radio-chemotherapies, have been demonstrated to induce trans-differentiation, cellular plasticity, activation of DNA damage response and stemness. <h4>Methods: </h4> Utilizing the Illumina 450K BeadCh...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ca45ff9d-78b2-599a-a23a-e65b5a63c9e7
DOI: 10.21203/rs.3.rs-1407692/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Differential DNA Methylation Patterns in Primary and Recurrent Glioblastoma : A Protumorigenic Role for the TEM8 GeneDOI 10.21203/rs.3.rs-1407692/v1Read

Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastomaSemantic proximity Read

DNA methylation remodeling in temozolomide resistant recurrent glioblastoma: comparing epigenetic dynamics in vitro and in vivoSemantic proximity Read

Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastomaSemantic proximity Read

Comprehensive portrait of recurrent glioblastoma multiforme in molecular and clinical characteristics.Semantic proximity Read

Epigenetic Alterations in Glioblastoma Multiforme as Novel Therapeutic Targets: A Scoping ReviewSemantic proximity Read

Glioblastoma Recurrence Correlates With Increased APE1 and Polarization Toward an Immuno-Suppressive MicroenvironmentSemantic proximity Read

Integrated longitudinal analysis of glioblastomas with long-term relapse interval revealed upregulation of the Tumor Growth Factor β signaling pathway in the recurrent tumorSemantic proximity Read

Genomic Landscape and Immunological Profile of Glioblastoma in East Asian PatientsSemantic proximity Read

Functional discovery of targetable dependencies in recurrent glioblastomaSemantic proximity Read

Genomic analysis reveals secondary glioblastoma after radiotherapy in a subset of recurrent medulloblastomasSemantic proximity Read

Interleukin-8/CXCR2 signaling regulates therapy-induced plasticity and enhances tumorigenicity in glioblastomaSemantic proximity Read

A multifaceted review of temozolomide resistance mechanisms in glioblastoma beyond O-6-methylguanine-DNA methyltransferaseSemantic proximity Read