Article

The Bardet-Biedl protein Bbs1 controls photoreceptor outer segment protein and lipid composition

2021-07-13

Abstract excerpt

<h4>Summary</h4> Primary cilia are key sensory organelles whose dysfunction leads to ciliopathy disorders such as Bardet-Biedl syndrome (BBS). Retinal degeneration is common in ciliopathies, since the outer segments (OSs) of photoreceptors are highly specialized primary cilia. BBS1, encoded by the most commonly mutated BBS-associated gene, is part of the BBSome protein complex. Using a new bbs1 zebrafish mutant,...

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Literature Corpus work: f12e6621-75a5-5390-8e2f-50df4a28e8b9
DOI: 10.1101/2021.07.13.452166

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