Article

UnitedMet harnesses RNA-metabolite covariation to impute metabolite levels in clinical samples

2024-05-25

Abstract excerpt

Comprehensively studying metabolism requires the measurement of metabolite levels. However, in contrast to the broad availability of gene expression data, metabolites are rarely measured in large molecularly-defined cohorts of tissue samples. To address this basic barrier to metabolic discovery, we propose a Bayesian framework (“UnitedMet”) which leverages the empirical strength of RNA-metabolite covariation to im...

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Identifiers and source

Literature Corpus work: 19db1e6b-4833-5330-895f-189ba67bc7f7
DOI: 10.1101/2024.05.24.24307903

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