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Article

Tobacco smoking induces metabolic reprogramming of renal cell carcinoma

24 Sept 2020

Abstract excerpt

BACKGROUNDClear cell renal cell carcinoma (ccRCC) is the most common histologically defined renal cancer. However, it is not a uniform disease and includes several genetic subtypes with different prognoses. ccRCC is also characterized by distinctive metabolic reprogramming. Tobacco smoking (TS) is an established risk factor for ccRCC, with unknown effects on tumor pathobiology.METHODSWe investigated the landscape...

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Share to Cancer, Hypoxia, and Metabolism
Share to Epigenetics and DNA Methylation
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PMID: 32970633
DOI: 10.1172/jci140522

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