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Article

Immunometabolic coevolution defines unique microenvironmental niches in ccRCC

5 Jul 2023

Abstract excerpt

Tumor cell phenotypes and anti-tumor immune responses are shaped by local metabolite availability, but intratumoral metabolite heterogeneity (IMH) and its phenotypic consequences remain poorly understood. To study IMH, we profiled tumor/normal regions from clear cell renal cell carcinoma (ccRCC) patients. A common pattern of IMH transcended all patients, characterized by correlated fluctuations in the abundance...

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PMID: 37413991
DOI: 10.1016/j.cmet.2023.06.005

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