Article

Spatial multi-omics enables single-cell transcriptome–metabolome inference

2026-08-12

Abstract excerpt

Joint single-cell transcriptomic–metabolomic profiling remains technically intractable. Here we present CHIMERA ( C ell-level H ybrid I nference of M etabolome E mbedded on R NA A tlas), a data-driven framework that learns transcriptome-to-metabolome mappings from spatially paired multi-omics data and transfers them to unpaired scRNA-seq. CHIMERA generates quantitative, database-independent single-cell meta...

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Literature Corpus work: 6355411c-8efc-57dc-adff-edc2ed21314e
DOI: 10.64898/2026.08.06.743252

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