Article

Expression-Driven Genetic Dependency Reveals Targets for Precision Medicine

2024-10-21

Abstract excerpt

Cancer cells are heterogeneous, each harboring distinct molecular aberrations and are dependent on different genes for their survival and proliferation. While successful targeted therapies have been developed based on driver DNA mutations, many patient tumors lack druggable mutations and have limited treatment options. Here, we hypothesize that new precision oncology targets may be identified through “expression-d...

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Literature Corpus work: 19c2bdde-ae4d-5bc2-a266-cb340e284008
DOI: 10.1101/2024.10.17.618926

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