Article

BOGO: A Proteome-Wide Gene Overexpression Platform for Discovering Rational Cancer Combination Therapies

2025-09-07

Abstract excerpt

Cancer drug resistance remains a major barrier to durable treatment success, often leading to relapse despite advances in precision oncology. While combination therapies are being increasingly investigated, such as chemotherapy with small molecule inhibitors, predicting drug response and identifying rational drug combinations based on resistance mechanisms remain major challenges. Therefore, a proteome-wide, singl...

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Literature Corpus work: 35906e3d-10ec-5b6c-b058-3c5ad02192d5
DOI: 10.1101/2025.09.02.673780

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