Article

Characterizing the landscape of gene process dependencies in cancer

2025-11-16

Abstract excerpt

Precision oncology aims to tailor cancer treatment to tumor genetics but it currently benefits only a small fraction of patients, in part because the primary focus is to match drug targets to single genes. The Cancer Dependency Map Project (DepMap) aimed to characterize the landscape of single-gene dependencies, which increased the universe of potential drug targets. However, the common challenges of drug off targ...

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Literature Corpus work: cf1a858b-c298-5305-b8b5-1d87e47023c2
DOI: 10.1101/2025.11.14.688518

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