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Article

Stepwise chromatin and transcriptional acquisition of an intraepithelial lymphocyte program.

Nature immunology - 1 Apr 2021

London Mariya, Bilate Angelina M, Castro Tiago B R, Sujino Tomohisa, Mucida Daniel

Abstract excerpt

Mesenteric lymph node (mLN) T cells undergo tissue adaptation upon migrating to intestinal lamina propria and epithelium, ensuring appropriate balance between tolerance and resistance. By combining mouse genetics with single-cell and chromatin analyses, we uncovered the molecular imprinting of gut epithelium on T cells. Transcriptionally, conventional and regulatory (Treg) CD4+ T cells from mLN, lamina propria...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33686285
DOI: 10.1038/s41590-021-00883-8
PMCID: PMC8251700

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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