Article

PRAME induces genomic instability in uveal melanoma

2023-04-26

Abstract excerpt

<title>Abstract</title> <p>PRAME is a CUL2 ubiquitin ligase subunit that is normally expressed in the testis but becomes aberrantly overexpressed in many cancer types in association with aneuploidy and metastasis. Here, we show that PRAME is expressed predominantly in spermatogonia around the time of meiotic crossing-over in coordination with genes mediating DNA double strand break repair. Expression of PRAME in...

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Literature Corpus work: 19775631-bd38-55cd-a99e-b4e4db04c397
DOI: 10.21203/rs.3.rs-2861359/v1

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