Article
An animal model recapitulates human hepatic diseases associated with GATA6 mutations.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2025
Shi Wenpeng, Yi Xiaogui, Ruan Hua, Wang Donglei, Wu Dan, Jiang Pengfei, Luo Lisha, Ma Xirui, Jiang Faming, Li Cairui, Wu Weinan, Luo Lingfei, Li Li, Wang Guixue, Qiu Juhui, Huang Honghui
Abstract excerpt
Heterozygotic GATA6 mutations are responsible for various congenital diseases in the heart, pancreas, liver, and other organs in humans. However, there is lack of an animal that can comprehensively model these diseases since GATA6 is essential for early embryogenesis. Here, we report the establishment of a gata6 knockout zebrafish which recapitulates most of the symptoms in patients with GATA6 mutations,...
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