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A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease.

Development (Cambridge, England) - 1 Aug 2005

Sadler Kirsten C, Amsterdam Adam, Soroka Carol, Boyer James, Hopkins Nancy

Abstract excerpt

Hepatomegaly is a sign of many liver disorders. To identify zebrafish mutants to serve as models for hepatic pathologies, we screened for hepatomegaly at day 5 of embryogenesis in 297 zebrafish lines bearing mutations in genes that are essential for embryonic development. Seven mutants were identified, and three have phenotypes resembling different liver diseases. Mutation of the class C vacuolar protein sorting...

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PMID: 16000385
DOI: 10.1242/dev.01918

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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