Article
Mutations affecting liver development and function in Medaka, Oryzias latipes, screened by multiple criteria.
Mechanisms of development - 1 Jul 2004
Watanabe Tomomi, Asaka Satoshi, Kitagawa Daiju, Saito Kota, Kurashige Ryumei, Sasado Takao, Morinaga Chikako, Suwa Hiroshi, Niwa Katsutoshi, Henrich Thorsten, Hirose Yukihiro, Yasuoka Akihito, Yoda Hiroki, Deguchi Tomonori, Iwanami Norimasa, Kunimatsu Sanae, Osakada Masakazu, Loosli Felix, Quiring Rebecca, Carl Matthias, Grabher Clemens, Winkler Sylke, Del Bene Filippo, Wittbrodt Joachim, Abe Keiko, Takahama Yousuke, Takahashi Katsuhito, Katada Toshiaki, Nishina Hiroshi, Kondoh Hisato, Furutani-Seiki Makoto
Abstract excerpt
We report here mutations affecting various aspects of liver development and function identified by multiple assays in a systematic mutagenesis screen in Medaka. The 22 identified recessive mutations assigned to 19 complementation groups fell into five phenotypic groups. Group 1, showing defective liver morphogenesis, comprises mutations in four genes, which may be involved in the regulation of growth or...
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