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Article

NCK-associated protein 1 like (nckap1l) minor splice variant regulates intrahepatic biliary network morphogenesis.

PLoS genetics - 1 Mar 2021

Ghaffari Kimia, Pierce Lain X, Roufaeil Maria, Gibson Isabel, Tae Kevin, Sahoo Saswat, Cantrell James R, Andersson Olov, Lau Jasmine, Sakaguchi Takuya F

Abstract excerpt

Impaired formation of the intrahepatic biliary network leads to cholestatic liver diseases, which are frequently associated with autoimmune disorders. Using a chemical mutagenesis strategy in zebrafish combined with computational network analysis, we screened for novel genes involved in intrahepatic biliary network formation. We positionally cloned a mutation in the nckap1l gene, which encodes a cytoplasmic...

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Share to Bile Ducts, Intrahepatic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33739979
DOI: 10.1371/journal.pgen.1009402
PMCID: PMC8032155

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