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Article

Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells

12 Dec 2013

Abstract excerpt

Age is the greatest risk factor for cardiovascular disease. In addition, inflammation and age (senescence) have been linked at both the clinical and molecular levels. In general, senescent cells have been described as pro-inflammatory based on their senescence associated secretory phenotype (SASP). However, we have previously shown that senescence induced by overexpression ofSENEX (or ARHGAP18), in endothelial...

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PMID: 24334613
DOI: 10.18632/aging.100622

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