Article

Age-associated erosion of organ-specific endothelial programs compromises tissue function and resilience

2026-07-07

Abstract excerpt

<h4>SUMMARY</h4> Endothelial cells (ECs) express organ-specific gene programs supporting tissue homeostasis and resilience. However, the mechanisms by which aging reshapes these organ-specific endothelial programs and how the resulting changes affect tissue homeostasis, resilience, and disease susceptibility remain largely unknown. Herein, we performed single-cell RNA sequencing of ECs harvested from five organs...

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Literature Corpus work: 7dfc5972-03a2-565d-a180-27f8500a1f56
DOI: 10.64898/2026.07.02.735775

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