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Oxygen-sensitive TERT Promoter Methylation Regulates Telomerase Activity

2022-11-03

Abstract excerpt

Telomere repeats at the ends of human chromosomes protect chromosomes from degradation, and telomerase has a prominent role in telomere maintenance. Telomerase also affects cell proliferation, DNA replication, differentiation, and tumourigenesis. TERT (telomerase reverse transcriptase enzyme) is the catalytic subunit of telomerase and is critical for enzyme activity. TERT promoter mutations and promoter methylatio...

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Identifiers and source

Literature Corpus work
197016d9-1adb-54e8-ae80-ca8044bcb3b9
DOI
10.20944/preprints202211.0074.v1
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Oxygen-sensitive TERT Promoter Methylation Regulates Telomerase ActivityDOI 10.20944/preprints202211.0074.v1
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