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Microenvironmental Regulation of Telomerase Isoforms in Human Embryonic Stem Cells

22 Apr 2014

Abstract excerpt

Recent evidence points to extra-telomeric, noncanonical roles for telomerase in regulating stem cell function. In this study, human embryonic stem cells (hESCs) were cultured in 20% or 2% O2 microenvironments for up to 5 days and evaluated for telomerase reverse transcriptase (TERT) expression and telomerase activity. Results showed increased cell survival and maintenance of the undifferentiated state with...

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Identifiers

PMID: 24749509
DOI: 10.1089/scd.2013.0373

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