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Identification of transporters essential for survival of <i>Leishmania</i> promastigotes in the digestive tract of sand flies

2025-07-10

Abstract excerpt

Leishmania amastigotes ingested by female phlebotomine sand flies are exposed to a harsh and dynamic environment that differs markedly from the intracellular niche in the mammalian host in temperature, pH and nutrient availability. Membrane transporter proteins, channels and pumps play a crucial role in maintaining cellular physiology under changing environments. A systematic loss-of-function screen of the L. mex...

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Literature Corpus work
ccc313e2-f10e-5b6f-9fa2-6e395de6a21c
DOI
10.1101/2025.07.07.663555
Open publication

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Identification of transporters essential for survival of <i>Leishmania</i> promastigotes in the digestive tract of sand fliesDOI 10.1101/2025.07.07.663555
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