Article

Subcellular thermal profiling enables the deep functional exploration of the mitochondrial proteome

2024-02-29

Abstract excerpt

Mitochondria are membrane-bound organelle hubs of cellular metabolism and signaling. The dysregulation of mitochondria is related to the genesis of several highly prevalent diseases, including cancer and cardiovascular disorders, urging the development of novel technologies to systematically study this organelle and its dynamics. Thermal proteome profiling (TPP) allows the unbiased study of the interactions of pro...

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Literature Corpus work: 1955e4db-d0cd-54e9-8509-6e5b81299289
DOI: 10.1101/2024.02.27.582308

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