Article
Mass spectrometry-based proteomics to study mutants and interactomes of mitochondrial translocation proteins.
Methods in enzymology - 1 Jan 2024
Oeljeklaus Silke, Sharma Lakshita, Bender Julian, Warscheid Bettina
Abstract excerpt
The multiple functions of mitochondria are governed by their proteome comprising 1000-1500 proteins depending on the organism. However, only few proteins are synthesized inside mitochondria, whereas most are "born" outside mitochondria. To reach their destined location, these mitochondrial proteins follow specific import routes established by a mitochondrial translocase network. A detailed understanding of the...
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