Article

Integration of Thermal Proteome Profiling with phosphoproteomic and transcriptomic data via mechanistic network models decodes the molecular response to PARP inhibition

2023-08-16

Abstract excerpt

The deregulation of complex diseases often spans multiple molecular processes. A multimodal functional characterization of these processes can shed light on the disease mechanisms and the effect of drugs. Thermal Proteome Profiling (TPP) is a mass-spectrometry based technique assessing changes in thermal protein stability that can serve as proxies of functional changes of the proteome. These unique insights of TPP...

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Literature Corpus work: 80d65ec1-9db3-5d6c-89ac-43b9e6bd9ad0
DOI: 10.1101/2023.08.15.553354

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