Direct detection of natural selection in Bronze Age Britain

Abstract excerpt

We developed a novel method for efficiently estimating time-varying selection coefficients from genome-wide ancient DNA data. In simulations, our method accurately recovers selective trajectories, and is robust to mis-specification of population size. We applied it to a large dataset of ancient and present-day human genomes from Britain, and identified seven loci with genome-wide significant evidence of selection...

Topics

Open a Topic to create a Post that cites this publication.

• Algorithms
• Computer Simulation
• DNA, Ancient
• Evolution, Molecular
• Likelihood Functions
• Markov Chains
• Models, Genetic
• Selection, Genetic

Identifiers and source

Literature Corpus work

1944d9d2-df1c-5163-8d9a-884467a4680b

DOI

10.1101/2022.03.14.484330