Article

Fast and accurate estimation of selection coefficients and allele histories from ancient and modern DNA

2023-12-17

Abstract excerpt

We here present CLUES2, a full-likelihood method to infer natural selection from sequence data that is an extension of the method CLUES. We make several substantial improvements to the CLUES method that greatly increases both its applicability and its speed. We add the ability to use ARGs on ancient data as emissions to the underlying HMM, which enables CLUES2 to use both temporal and linkage information to make e...

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Literature Corpus work: 6d7d2535-f52c-5149-95fa-3c496cee76c6
DOI: 10.1101/2023.12.16.572012

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