Fast and Accurate Estimation of Selection Coefficients and Allele Histories from Ancient and Modern DNA.

Abstract excerpt

We here present CLUES2, a full-likelihood method to infer natural selection from sequence data that is an extension of the method CLUES. We make several substantial improvements to the CLUES method that greatly increases both its applicability and its speed. We add the ability to use ancestral recombination graphs on ancient data as emissions to the underlying hidden Markov model, which enables CLUES2 to use both...

Topics

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• Algorithms
• Computer Simulation
• DNA, Ancient
• Evolution, Molecular
• Likelihood Functions