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Article

Differential role of cytosolic Hsp70s in longevity assurance and protein quality control.

PLoS genetics - 1 Jan 2021

Andersson Rebecca, Eisele-Bürger Anna Maria, Hanzén Sarah, Vielfort Katarina, Öling David, Eisele Frederik, Johansson Gustav, Gustafsson Tobias, Kvint Kristian, Nyström Thomas

Abstract excerpt

70 kDa heat shock proteins (Hsp70) are essential chaperones of the protein quality control network; vital for cellular fitness and longevity. The four cytosolic Hsp70's in yeast, Ssa1-4, are thought to be functionally redundant but the absence of Ssa1 and Ssa2 causes a severe reduction in cellular reproduction and accelerates replicative aging. In our efforts to identify which Hsp70 activities are most important...

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Identifiers

PMID: 33428620
DOI: 10.1371/journal.pgen.1008951
PMCID: PMC7822560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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