Article

Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish

2024-10-27

Abstract excerpt

Microexons exhibit striking evolutionary conservation and are subject to precise, switch-like regulation in neurons, orchestrated by the splicing factors Srrm3 and Srrm4 . Disruption of these regulators in mice leads to severe neurological phenotypes, and their misregulation is linked to human disease. However, the specific microexons involved in these phenotypes and the effects of individual microexon deletions...

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Identifiers and source

Literature Corpus work: 18fad457-2a65-518a-87b5-691b522eb4cd
DOI: 10.1101/2024.10.23.619860

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