Article

Unique and overlapping behavioral effects of isoform-specific NRXN1 deletions across development

2026-01-22

Abstract excerpt

Mutations in the human neurexin 1 (NRXN1) gene are associated with neurodevelopmental disorders including autism and schizophrenia. Vertebrate NRXN1 produces three major NRXN1 isoforms, named α, β , and γ . Human genetic data suggests that deletions located at the 5’ region of the gene disrupting the α isoform associate mostly with clinical behavioral deficits. Yet, 3’ deletions that disrupt multiple isoforms h...

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Literature Corpus work: b66f1079-1641-5b6a-95eb-90342fc5c5ff
DOI: 10.64898/2026.01.22.698702

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